Upregulation of Glt1 Attenuates Cue-Induced Reinstatement of Cocaine-Seeking Behavior in Rats

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Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats.

Relapse to cocaine-seeking behavior depends on increased glutamate transmission in key regions of the mesocorticolimbic motive circuit, including prefrontal cortex (PFC) and nucleus accumbens (NAcc). Because GLT1 is responsible for the uptake of >or=90% of extracellular glutamate, we tested the hypothesis that increased GLT1 expression attenuates cocaine relapse. Rats were trained to self-admin...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2009

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.1746-09.2009